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Measured values represent approximate 'normal' levels in sample, but do not signify the only possible sample levels. Various factors (e.g. sample storage, assay procedure) can affect results.
Data may differ slightly based on lot.
Data may differ slightly based on lot.
|1.29 - 27.5 ng/ml|
||Store at 4°C|
Circulating irisin levels in heart failure with preserved or reduced ejection fraction: A pilot study.
Silvestrini A, Bruno C, Vergani E, et al. PLoS ONE. 2019;14(1):e0210320.
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models.
Lourenco MV, Frozza RL, De freitas GB, et al. Nat Med. 2019;25(1):165-175.
Association of serum concentrations of irisin and the adipokines adiponectin and leptin with epicardial fat in cardiovascular surgery patients.
Kaneda H, Nakajima T, Haruyama A, et al. PLoS ONE. 2018;13(8):e0201499.
Irisin Maternal Plasma and Cord Blood Levels in Mothers with Spontaneous Preterm and Term Delivery.
Pavlova T, Zlamal F, Tomandl J, Hodicka Z, Gulati S, Bienertova-vasku J. Dis Markers. 2018;2018:7628957.
Does high intensity exercise affects irisin plasma levels in hemodialysis patients? A pilot study.
Esgalhado MGBM, Stockler-pinto MB, Cardozo LFMF, Barboza JE, Mafra D. J Bras Nefrol. 2018;40(1):53-58.
Retinoic Acid Increases Fatty Acid Oxidation and Irisin Expression in Skeletal Muscle Cells and Impacts Irisin In Vivo.
Amengual J, García-carrizo FJ, Arreguín A, et al. Cell Physiol Biochem. 2018;46(1):187-202.
Lower Serum Irisin Levels Are Associated with Increased Vascular Calcification in Hemodialysis Patients.
He L, He WY, A LT, Yang WL, Zhang AH. Kidney Blood Press Res. 2018;43(1):287-295.
Exercise-induced irisin release as a determinant of the metabolic response to exercise training in obese youth: the EXIT trial.
Devin R. Blizzard LeBlanc, Brittany V. Rioux, Cody Pelech et al., Physiol Rep. 2017 Dec; 5(23): e13539.
Serum irisin levels correlated to peritoneal dialysis adequacy in nondiabetic peritoneal dialysis patients.
Tan Z, Ye Z, Zhang J, et al. PLoS ONE. 2017;12(4):e0176137.
Irisin: A Potential Link between Physical Exercise and Metabolism-An Observational Study in Differently Trained Subjects, from Elite Athletes to Sedentary People.
Benedini S, Dozio E, Invernizzi PL, et al. J Diabetes Res. 2017;2017:1039161.
Plasma Irisin Modestly Increases during Moderate and High-Intensity Afternoon Exercise in Obese Females.
Winn NC, Grunewald ZI, Liu Y, Heden TD, Nyhoff LM, Kanaley JA. PLoS ONE. 2017;12(1):e0170690.
Association of Serum Irisin Concentrations with Presence and Severity of Coronary Artery Disease.
Deng W. Med Sci Monit. 2016;22:4193-4197.
Effects of Body Weight Reduction on Serum Irisin and Metabolic Parameters in Obese Subjects.
Fukushima Y, Kurose S, Shinno H, et al. Diabetes Metab J. 2016;40(5):386-395.
Circulating Levels of Irisin in Hypopituitary and Normal Subjects.
Pena-Bello L, Pértega-Diaz S, Sangiao-Alvarellos S, et al. Luque RM, ed. PLoS ONE. 2016;11(7):e0160364.
High Serum Irisin Level as an Independent Predictor of Diabetes Mellitus: A Longitudinal Population-Based Study.
Huh JH, Ahn SV, Choi JH, Koh SB, Chung CH. Medicine (Baltimore). 2016;95(23):e3742.
Irisin Is Regulated by CAR in Liver and Is a Mediator of Hepatic Glucose and Lipid Metabolism.
Mo L, Shen J, Liu Q, et al. Mol Endocrinol. 2016;30(5):533-42.
Irisin modulates the association of interleukin-17A with the presence of non-proliferative diabetic retinopathy in patients with type 2 diabetes.
Wang C, Wang L, Liu J, et al. Endocrine. 2016;53(2):459-64.
Time-dependent irisin concentration changes in patients affected by overt hypothyroidism.
Zybek-kocik A, Sawicka-gutaj N, Wrotkowska E, Sowi?ski J, Rucha?a M. Endokrynol Pol. 2016;67(5):476-480.
Circulating Adipocyte Fatty Acid Binding Protein (FABP4) Levels Are Associated with Irisin in the Middle-Aged General Chinese Population.
Zhang S, Yang L, Chen P, et al. PLoS ONE. 2016;11(1):e0146605.
Effects and Molecular Mechanism of GST-Irisin on Lipolysis and Autocrine Function in 3T3-L1 Adipocytes.
Gao S, Li F, Li H, Huang Y, Liu Y, Chen Y. PLoS ONE. 2016;11(1):e0147480.
Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes.
Liu TY, Shi CX, Gao R, et al. Clin Sci. 2015;129(10):839-50.
Betatrophin levels are increased in women with gestational diabetes mellitus compared to healthy pregnant controls.
Ebert T, Kralisch S, Wurst U, et al. Eur J Endocrinol. 2015;173(1):1-7.
Circulating irisin is lower in gestational diabetes mellitus.
Zhao L, Li J, Li ZL, Yang J, Li ML, Wang GL. Endocr J. 2015;62(10):921-6.
Irisin in blood increases transiently after single sessions of intense endurance exercise and heavy strength training.
Nygaard H, Slettaløkken G, Vegge G, et al. PLoS ONE. 2015;10(3):e0121367.
Associations of betatrophin levels with irisin in Chinese women with normal glucose tolerance.
Xie X, Gao T, Yang M, et al. Diabetol Metab Syndr. 2015;7:26.
Elevated circulating levels of irisin and the effect of metformin treatment in women with polycystic ovary syndrome.
Li M, Yang M, Zhou X, et al. J Clin Endocrinol Metab. 2015;100(4):1485-93.
Plasma irisin in runners and nonrunners: no favorable metabolic associations in humans.
Hew-butler T, Landis-piwowar K, Byrd G, et al. Physiol Rep. 2015;3(1)
Impact of supervised exercise rehabilitation on daily physical activity of cardiopulmonary patients.
Ramadi A, Stickland MK, Rodgers WM, Haennel RG. Heart Lung. 2015;44(1):9-14.
Complexity-Based Measures Inform Effects of Tai Chi Training on Standing Postural Control: Cross-Sectional and Randomized Trial Studies.
Wayne PM, Gow BJ, Costa MD, et al. PLoS ONE. 2014;9(12):e114731.
Thermogenic capacity is antagonistically regulated in classical brown and white subcutaneous fat depots by high fat diet and endurance training in rats: impact on whole-body energy expenditure.
Wu MV, Bikopoulos G, Hung S, Ceddia RB. J Biol Chem. 2014;289(49):34129-40.
Brown adipose tissue improves whole-body glucose homeostasis and insulin sensitivity in humans.
Chondronikola M, Volpi E, Børsheim E, et al. Diabetes. 2014;63(12):4089-99.
Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans.
Lee P, Linderman JD, Smith S, et al. Cell Metab. 2014;19(2):302-9.
The identification of irisin in human cerebrospinal fluid: influence of adiposity, metabolic markers, and gestational diabetes.
Piya MK, Harte AL, Sivakumar K, et al. Am J Physiol Endocrinol Metab. 2014;306(5):E512-8.
Serum levels of irisin in gestational diabetes mellitus during pregnancy and after delivery.
Ebert T, Stepan H, Schrey S, et al. Cytokine. 2014;65(2):153-8.
Plasma irisin depletion under energy restriction is associated with improvements in lipid profile in metabolic syndrome patients.
De la iglesia R, Lopez-legarrea P, Crujeiras AB, et al. Clin Endocrinol (Oxf). 2014;81(2):306-11.
Irisin and FNDC5 in retrospect: An exercise hormone or a transmembrane receptor?.
Erickson HP. Adipocyte. 2013;2(4):289-93.
Exercise training does not increase muscle FNDC5 protein or mRNA expression in pigs.
Fain JN, Company JM, Booth FW, et al. Metab Clin Exp. 2013;62(10):1503-11.
Resistance exercise training does not affect plasma irisin levels of hemodialysis patients.
Moraes C, Leal VO, Marinho SM, et al. Horm Metab Res. 2013;45(12):900-4.
Circulating irisin in relation to insulin resistance and the metabolic syndrome.
Park KH, Zaichenko L, Brinkoetter M, et al. J Clin Endocrinol Metab. 2013;98(12):4899-907.
Effects of obesity, diabetes and exercise on Fndc5 gene expression and irisin release in human skeletal muscle and adipose tissue: in vivo and in vitro studies.
Kurdiova T, Balaz M, Vician M, et al. J Physiol (Lond). 2014;592(5):1091-107.
The effects of acute and chronic exercise on PGC-1α, irisin and browning of subcutaneous adipose tissue in humans.
Norheim F, Langleite TM, Hjorth M, et al. FEBS J. 2014;281(3):739-49.