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Relaxin 2 (Human)

Quantity:

Catalog #
Size
Price
035-62 20 µg $202

Sequence:  ()
A Chain:
pGlu-Leu-Tyr-Ser-Ala-Leu-Ala-Asn-Lys-Cys-Cys-His-Val-Gly-Cys-Thr-Lys-Arg-Ser-Leu-Ala-Arg-Phe-Cys
B Chain:
Asp-Ser-Trp-Met-Glu-Glu-Val-Ile-Lys-Leu-Cys-Gly-Arg-Glu-Leu-Val-Arg-Ala-Gln-Ile-Ala-Ile-Cys-Gly-Met-Ser-Thr-Trp-Ser
Disulfide bridge(s): CysA10-CysA15, CysA11-CysB11, CysA24-CysB23
  • Molecular Weight:
  • 5963.06
  • Purity:
  • ≥ 90%
  • Validation:
  • Exhibits correct molecular weight
  • Solubility:
  • Soluble in water
  • Storage:
  • Up to 6 months in lyophilized form at 0-5°C.
    For best results, rehydrate just before use.
    After rehydration, keep solution at +4°C for up to 5 days or freeze at -20°C for up to 3 months. Aliquot before freezing to avoid repeated freeze-thaw cycles.
  • Appearance:
  • White powder
  • Contents:
  • Each vial contains 20 µg of NET peptide.
  • MSDS:
  • View/Download
Structure:


Relaxin in paraventricular nucleus contributes to sympathetic overdrive and hypertension via PI3K-Akt pathway.
Sun HJ, Chen D, Han Y, et al. Neuropharmacology. 2016;103:247-56.

H2 and H3 relaxin inhibit high glucose-induced apoptosis in neonatal rat ventricular myocytes.
Zhang X, Ma X, Zhao M, et al. Biochimie. 2015;108:59-67.

Relaxin affects cell organization and early and late stages of spermatogenesis in a coculture of rat testicular cells.
Pimenta MT, Francisco RA, Silva RP, Porto CS, Lazari MF. Andrology. 2015;3(4):772-86.

The positive inotropic effect of relaxin-2 in human atrial myocardium is preserved in end-stage heart failure: role of G(i)-phosphoinositide-3 kinase signaling.
Dschietzig T, Alexiou K, Kinkel HT, Baumann G, Matschke K, Stangl K. J Card Fail. 2011;17(2):158-66.

Relaxin stimulates osteoclast differentiation and activation.
Ferlin A, Pepe A, Facciolli A, Gianesello L, Foresta C. Bone. 2010;46(2):504-13.

Autoregulation of human relaxin-2 gene expression critically involves relaxin and glucocorticoid receptor binding to glucocorticoid response half-sites in the relaxin-2 promoter.
Dschietzig T, Bartsch C, Wessler S, Baumann G, Stangl K. Regul Pept. 2009;155(1-3):163-73.

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