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Irisin, recombinant (Human, Rat, Mouse, Canine)

Quantity:
Catalog #
Size
Price
067-29 10 µg $77

Sequence:  ()
Asp-Ser-Pro-Ser-Ala-Pro-Val-Asn-Val-Thr-Val-Arg-His-Leu-Lys-Ala-Asn-Ser-Ala-Val-Val-Ser-Trp-Asp-Val-Leu-Glu-Asp-Glu-Val-Val-Ile-Gly-Phe-Ala-Ile-Ser-Gln-Gln-Lys-Lys-Asp-Val-Arg-Met-Leu-Arg-Phe-Ile-Gln-Glu-Val-Asn-Thr-Thr-Thr-Arg-Ser-Cys-Ala-Leu-Trp-Asp-Leu-Glu-Glu-Asp-Thr-Glu-Tyr-Ile-Val-His-Val-Gln-Ala-Ile-Ser-Ile-Gln-Gly-Gln-Ser-Pro-Ala-Ser-Glu-Pro-Val-Leu-Phe-Lys-Thr-Pro-Arg-Glu-Ala-Glu-Lys-Met-Ala-Ser-Lys-Asn-Lys-Asp-Glu-Val-Thr-Met-Lys-Glu
  • Molecular Weight:
  • 12.5 kDa
  • Validation:
  • Exhibits correct molecular weight
  • Solubility:
  • Soluble in water (0.1-1.0 mg/ml). Then dilute with water or any desired aqueous buffer.
  • Storage:
  • Store in dried form at -80°C for up to 3 months.
    For best results, rehydrate just before use.
    After rehydration, keep at +4°C for 1 week or at -80°C for longer-term storage. Aliquot before freezing to avoid repeated freeze-thaw cycles.
  • Appearance:
  • White powder
  • Contents:
  • Each vial contains 10 µg of protein.

Effects and underlying mechanisms of irisin on the proliferation and apoptosis of pancreatic β cells. 
Liu S, Du F, Li X, et al. PLoS ONE. 2017;12(4):e0175498.

Exercise-indusced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism.
Zhang J, Valverde P, Zhu X, et al. Bone Research. 2017;5:16056.

Irisin Lowers Blood Pressure by Improvement of Endothelial Dysfunction via AMPK-Akt-eNOS-NO Pathway in the Spontaneously Hypertensive Rat.
Fu J, Han Y, Wang J, et al. J Am Heart Assoc. 2016;5(11)

FNDC5 expression and circulating irisin levels are modified by diet and hormonal conditions in hypothalamus, adipose tissue and muscle.
Varela-rodríguez BM, Pena-bello L, Juiz-valiña P, Vidal-bretal B, Cordido F, Sangiao-alvarellos S. Sci Rep. 2016;6:29898.

Irisin evokes bradycardia by activating cardiac-projecting neurons of nucleus ambiguus.
Brailoiu E, Deliu E, Sporici RA, Brailoiu GC. Physiol Rep. 2015;3(6)

Central and peripheral irisin differentially regulate blood pressure.
Zhang W, Chang L, Zhang C, et al. Cardiovasc Drugs Ther. 2015;29(2):121-7.

Irisin, a Novel Myokine, Regulates Glucose Uptake in Skeletal Muscle Cells via AMPK.
Lee HJ, Lee JO, Kim N, et al. Mol Endocrinol. 2015;29(6):873-81.

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