(1) as a phosphaturic factor to induce hypophosphatemia, and low 1a,25(OH)2D3 synthesis with a reduction in the expression of 1a hydroxylase, leading to a negative P balance. Binding to Klotho protein to control mineral metabolism, vitamin D homeostasis, insulin/glucose, oxidative stress, and vascular calcifications.
Isakova T. et al, JAMA. 2011 Jun 15;305(23):2432-9.
(2) Fibroblast growth factor 23 acts on the parathyroid to decrease parathyroid hormone secretion.
Galitzer H, et al., Curr Opin Nephrol Hypertens. 2008 Jul;17(4):363-7.
(3) Increased level of FGF-23 has been linked to CVD and death of patients with Chronic Kidney Disease.
Wolf M. Clin J Am Soc Nephrol 5: 1727?729, 2010.