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A New Physiological Opponent of Ghrelin

ghrelin and obestatin schematics
rat prepro ghrelinhuman prepro ghrelin
The ghrelin receptor family. A, schematic phylogenic tree of the ghrelin receptor family indicating the relative relationship of the receptor. The black dots indicate the three receptors that either previously (the ghrelin receptor and NT-R2 (8, 17)) or in the present study (GPR39) have been demonstrated to display a high degree of constitutive signaling activity. B, serpentine model of GPR39. Residues that are identical among GPR39, the ghrelin receptor, and NT-R2 are highlighted in white on black. The generic numbering system for 7TM receptor residues described by Schwartz (59) is used throughout the article, and the proposed first residues of each transmembrane helix are indicated by 1.

Holst B, et al. J Biol Chem. 2004 Dec 17;279(51):53806-17. Epub 2004 Sep 21.

Updates coming soon.

The ghrelin-motilin receptor family and their ligands. The ghrelin-motilin receptor family and their ligands. Each of these gastrointestinal hormones acts on a specific G protein-coupled receptor from the same family to affect food intake and gastrointestinal motility (9-11). Similar dual effects on satiety and gastrointestinal motility are known for glucagon-like peptide 1, cholecystokinine, or peptide YY. Collectively, these peptides may serve to couple meal termination with inhibition of upper gastrointestinal function to prevent ma labsorption and postprandial metabolic disturbances (1, 2, 8). 

Ruben Nogueiras and Matthias Tschöp. Science, Vol 310, Issue 5750, 985-986 , 11 November 2005

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Catalog# Product Standard Size Price
031-90 Obestatin (Rat, Mouse) 100 µg $82
032-62 Obestatin (1-4) amide 200 µg $112
031-85 Obestatin (Bovine) 100 µg $133
031-99 Obestatin (Canine) 100 µg $133
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031-16 [Tyr1, Ser16]-Obestatin (Human, Monkey) 100 µg $184
031-18 [3,4-Dehydro-Pro4]-Obestatin (Human, Monkey) 100 µg $130
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031-92 Obestatin (Human, Monkey) 100 µg $82
H-031-92 Obestatin (Human, Monkey) - Antibody 100 µl $459
B-031-92 Obestatin (Human, Monkey) - Biotin Labeled 10 µg $255
B-G-031-92 Obestatin (Human, Monkey) - Biotin Labeled Purified IgG 100 µl $612
FC3-031-92 Obestatin (Human, Monkey) - Cy3 Labeled 1 nmol $357
FC3-G-031-92 Obestatin (Human, Monkey) - Cy3 Labeled Purified IgG 100 µl $612
FC5-031-92 Obestatin (Human, Monkey) - Cy5 Labeled 1 nmol $357
FC5-G-031-92 Obestatin (Human, Monkey) - Cy5 Labeled Purified IgG 100 µl $612
FG-031-92A Obestatin (Human, Monkey) - FAM Labeled 1 nmol $255
FG-G-031-92A Obestatin (Human, Monkey) - FAM Labeled Purified IgG 100 µl $612
FG-031-92B Obestatin (Human, Monkey) - FITC Labeled 1 nmol $255
FG-G-031-92B Obestatin (Human, Monkey) - FITC Labeled Purified IgG 100 µl $612
T-031-16 [Tyr1, Ser16]-Obestatin (Human, Monkey) - I-125 Labeled 10 µCi $723
T-031-92 Obestatin (Human, Monkey) - I-125 Labeled 10 µCi $723
MRK-031-92 Obestatin (Human, Monkey) - Magnetic Bead RIA Kit 125 tubes $671
G-031-92 Obestatin (Human, Monkey) - Purified IgG Antibody 200 µg $505
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RKU-031-92 Obestatin (Human, Monkey) - Ultra-Sensitive RIA Kit 125 tubes $588
031-98 Obestatin (Porcine) 100 µg $133
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FC3-031-98 Obestatin (Porcine) - Cy3 Labeled 1 nmol $357
FG-031-98A Obestatin (Porcine) - FAM Labeled 1 nmol $255

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