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Humanin

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Humanin (HN), a 24-residue peptide, was identified as a novel neuroprotective factor and shows anti-cell death activity against a wide spectrum of Alzheimer's disease (AD)-related cytotoxicities, including exposure to amyloid beta (Abeta), in vitro. We previously demonstrated that the injection of S14G-HN, a highly potent HN derivative, into brain ameliorated memory loss in an Abeta-injection mouse model. To fully understand HN's functions under AD-associated pathological conditions, we examined the effect of S14G-HN on triple transgenic mice harboring APP(swe), tau(P310L), and PS-1(M146V) that show the age-dependent development of multiple pathologies relating to AD. After 3 months of intranasal treatment, behavioral analyses showed that S14G-HN ameliorated cognitive impairment in male mice. Moreover, ELISA and immunohistochemical analyses showed that Abeta levels in brains were markedly lower in S14G-HN-treated male and female mice than in vehicle control mice. We also found the expression level of neprilysin, an Abeta degrading enzyme, in the outer molecular layer of hippocampal formation was increased in S14G-HN-treated mouse brains. NEP activity was also elevated by S14G-HN treatment in vitro. These findings suggest that decreased Abeta level in these mice is at least partly attributed to S14G-HN-induced increase of neprilysin level. Although HN was identified as an anti-neuronal death factor, these results indicate that HN may also have a therapeutic effect on amyloid accumulation in AD.

Niikura T, Sidahmed E, Hirata-fukae C, Aisen PS, Matsuoka Y. A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice. PLoS ONE. 2011;6(1):e16259.

 

Related Products

Catalog# Product Standard Size Price
018-26 Humanin, Nuclear-encoded / HN (N) (Human) 100 µg $133
018-25 Humanin, Mitochondria-encoded / HN (M) (Human) 100 µg $133
H-018-25 Humanin, Mitochondria-encoded / HN (M) (Human) - Antibody 50 µl $459
B-018-25 Humanin, Mitochondria-encoded / HN (M) (Human) - Biotin Labeled 20 µg $204
B-G-018-25 Humanin, Mitochondria-encoded / HN (M) (Human) - Biotin Labeled Purified IgG 100 µl $510
FC3-G-018-25 Humanin, Mitochondria-encoded / HN (M) (Human) - Cy3 Labeled Purified IgG 100 µl $561
FG-018-25A Humanin, Mitochondria-encoded / HN (M) (Human) - FAM Labeled 1 nmol $204
FG-G-018-25A Humanin, Mitochondria-encoded / HN (M) (Human) - FAM Labeled Purified IgG 100 µl $510
T-G-018-25 Humanin, Mitochondria-encoded / HN (M) (Human) - I-125 Labeled Purified IgG 10 µCi $723
G-018-25 Humanin, Mitochondria-encoded / HN (M) (Human) - Purified IgG Antibody 200 µg $459
FR-018-25 Humanin, Mitochondria-encoded / HN (M) (Human) - Rhodamine Labeled 1 nmol $204
H-018-26 Humanin, Nuclear-encoded / HN (N) (Human) - Antibody 100 µl $459
B-018-26 Humanin, Nuclear-encoded / HN (N) (Human) - Biotin Labeled 20 µg $204
FG-018-26A Humanin, Nuclear-encoded / HN (N) (Human) - FAM Labeled 1 nmol $204
FR-018-26 Humanin, Nuclear-encoded / HN (N) (Human) - Rhodamine Labeled 1 nmol $204
018-28 Humanin, Nuclear-encoded / HN (N) (Rat) 100 µg $194
H-018-28 Humanin, Nuclear-encoded / HN (N) (Rat) - Antibody 50 µl $459
B-018-28A Humanin, Nuclear-encoded / HN (N) (Rat) - Biotin Labeled 20 µg $204
B-G-018-28 Humanin, Nuclear-encoded / HN (N) (Rat) - Biotin Labeled Purified IgG 100 µl $510
EK-018-28 Humanin, Nuclear-encoded / HN (N) (Rat) - EIA Kit 96 wells $458
FG-018-28A Humanin, Nuclear-encoded / HN (N) (Rat) - FAM Labeled 1 nmol $286
FG-G-018-28A Humanin, Nuclear-encoded / HN (N) (Rat) - FAM Labeled Purified IgG 100 µl $510
T-G-018-28 Humanin, Nuclear-encoded / HN (N) (Rat) - I-125 Labeled Purified IgG 10 µCi $723
G-018-28 Humanin, Nuclear-encoded / HN (N) (Rat) - Purified IgG Antibody 200 µg $459
FR-018-28 Humanin, Nuclear-encoded / HN (N) (Rat) - Rhodamine Labeled 1 nmol $286
018-30 Humanin, Nuclear-encoded / [Gly14]-HN (N) (Human) 100 µg $163
FG-018-30A Humanin, Nuclear-encoded / [Gly14]-HN (N) (Human) - FAM Labeled 1 nmol $204
FR-018-30 Humanin, Nuclear-encoded / [Gly14]-HN (N) (Human) - Rhodamine Labeled 1 nmol $204
018-29 Humanin, Nuclear-encoded / [Pro8]-HN (N) (Human) 100 µg $163
FG-018-29A Humanin, Nuclear-encoded / [Pro8]-HN (N) (Human) - FAM Labeled 1 nmol $204

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