Menu

A new natural chemotactic ligand for FPRL2

Updates coming soon.

Chemotaxis of dendritic cells (DCs) and monocytes is a key step in the initiation of an adequate immune response. Formyl peptide receptor (FPR) and FPR-like receptor (FPRL)1, two G protein-coupled receptors belonging to the FPR family, play an essential role in host defense mechanisms against bacterial infection and in the regulation of inflammatory reactions. FPRL2, the third member of this structural family of chemoattractant receptors, is characterized by its specific expression on monocytes and DCs. Here, we present the isolation from a spleen extract and the functional characterization of F2L, a novel chemoattractant peptide acting specifically through FPRL2. F2L is an acetylated amino-terminal peptide derived from the cleavage of the human heme-binding protein, an intracellular tetrapyrolle-binding protein. The peptide binds and activates FPRL2 in the low nanomolar range, which triggers intracellular calcium release, inhibition of cAMP accumulation, and phosphorylation of extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases through the G(i) class of heterotrimeric G proteins. When tested on monocytes and monocyte-derived DCs, F2L promotes calcium mobilization and chemotaxis. Therefore, F2L appears as a new natural chemoattractant peptide for DCs and monocytes, and the first potent and specific agonist of FPRL2.

Migeotte I, Riboldi E, Franssen JD, et al. Identification and characterization of an endogenous chemotactic ligand specific for FPRL2. J Exp Med. 2005;201(1):83-93.


Updates coming soon.


Related Products

Catalog# Product Standard Size Price
072-35 F2L (1-21) / [Tyr10]-HBP (1-21) (Human, Canine, Porcine) 100 µg $122
T-072-35 F2L (1-21) / [Tyr10]-HBP (1-21) (Human, Canine, Porcine) - I-125 Labeled 10 µCi $780
072-36 F2L (1-21) / [Tyr10]-HBP (1-21) (Rat, Mouse) 100 µg $122
T-072-36 F2L (1-21) / [Tyr10]-HBP (1-21) (Rat, Mouse) - I-125 Labeled 10 µCi $780
072-29 F2L (1-21) / acetyl-HBP (1-21) (Human, Porcine, Canine) 100 µg $153
B-072-29 F2L (1-21) / acetyl-HBP (1-21) (Human, Porcine, Canine) - Biotin Labeled 10 µg $224
FC3-072-29 F2L (1-21) / acetyl-HBP (1-21) (Human, Porcine, Canine) - Cy3 Labeled 1 nmol $393
FC5-072-29 F2L (1-21) / acetyl-HBP (1-21) (Human, Porcine, Canine) - Cy5 Labeled 1 nmol $393
FG-072-29A F2L (1-21) / acetyl-HBP (1-21) (Human, Porcine, Canine) - FAM Labeled 1 nmol $224
FR-072-29 F2L (1-21) / acetyl-HBP (1-21) (Human, Porcine, Canine) - Rhodamine Labeled 1 nmol $281
072-33 F2L (1-21) / acetyl-HBP (1-21) (Rat, Mouse) 100 µg $153
072-63 F2L (1-21) / acetyl-[Tyr22]-HBP (1-21) (Human, Porcine, Canine) 100 µg $184
T-072-63 F2L (1-21) / acetyl-[Tyr22]-HBP (1-21) (Human, Porcine, Canine) - I-125 Labeled 10 µCi $780
072-30 F2L (1-21), nonacetylated / HBP (1-21), nonacetylated (Human, Porcine, Canine) 100 µg $153
H-072-30 F2L (1-21), nonacetylated / HBP (1-21), nonacetylated (Human, Porcine, Canine) - Antibody 100 µl $505
B-G-072-30 F2L (1-21), nonacetylated / HBP (1-21), nonacetylated (Human, Porcine, Canine) - Biotin Labeled Purified IgG 100 µl $561
FC3-G-072-30 F2L (1-21), nonacetylated / HBP (1-21), nonacetylated (Human, Porcine, Canine) - Cy3 Labeled Purified IgG 100 µl $668
FC5-G-072-30 F2L (1-21), nonacetylated / HBP (1-21), nonacetylated (Human, Porcine, Canine) - Cy5 Labeled Purified IgG 100 µl $668
FG-G-072-30A F2L (1-21), nonacetylated / HBP (1-21), nonacetylated (Human, Porcine, Canine) - FAM Labeled Purified IgG 100 µl $561
T-G-072-30 F2L (1-21), nonacetylated / HBP (1-21), nonacetylated (Human, Porcine, Canine) - I-125 Labeled Purified IgG 10 µCi $728
G-072-30 F2L (1-21), nonacetylated / HBP (1-21), nonacetylated (Human, Porcine, Canine) - Purified IgG Antibody 200 µg $505
072-34 F2L (1-21), nonacetylated / HBP (1-21), nonacetylated (Rat, Mouse) 100 µg $153
H-072-34 F2L (1-21), nonacetylated / HBP (1-21), nonacetylated (Rat, Mouse) - Antibody 100 µl $505
B-G-072-34 F2L (1-21), nonacetylated / HBP (1-21), nonacetylated (Rat, Mouse) - Biotin Labeled Purified IgG 100 µl $505
FC3-G-072-34 F2L (1-21), nonacetylated / HBP (1-21), nonacetylated (Rat, Mouse) - Cy3 Labeled Purified IgG 100 µl $668
FC5-G-072-34 F2L (1-21), nonacetylated / HBP (1-21), nonacetylated (Rat, Mouse) - Cy5 Labeled Purified IgG 100 µl $668
FG-G-072-34A F2L (1-21), nonacetylated / HBP (1-21), nonacetylated (Rat, Mouse) - FAM Labeled Purified IgG 100 µl $505
T-G-072-34 F2L (1-21), nonacetylated / HBP (1-21), nonacetylated (Rat, Mouse) - I-125 Labeled Purified IgG 10 µCi $780
G-072-34 F2L (1-21), nonacetylated / HBP (1-21), nonacetylated (Rat, Mouse) - Purified IgG Antibody 200 µg $505
072-31 F2L (7-21) / HBP (7-21) (Human, Rat, Mouse, Porcine, Canine) 100 µg $122