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Orexin A (Human, Rat, Mouse, Porcine, Ovine, Bovine, Monkey)

Quantity:

Catalog #
Size
Price
003-30 100 µg $189

Sequence:  ()
pGlu-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2
Disulfide bridge(s): Cys6-Cys12 & Cys7-Cys14
  • Molecular Weight:
  • 3561.15
  • Purity:
  • ≥ 95%
  • Validation:
  • Exhibits correct molecular weight
  • Solubility:
  • Soluble in water
  • Storage:
  • Up to 6 months in lyophilized form at 0-5°C.
    For best results, rehydrate just before use.
    After rehydration, keep solution at +4°C for up to 5 days or freeze at -20°C for up to 3 months. Aliquot before freezing to avoid repeated freeze-thaw cycles.
  • Appearance:
  • White powder
  • Contents:
  • Each vial contains 100 µg of NET peptide.

Presence, distribution and steroidogenic effect of the peptides orexin A and receptor 1 for orexins in the testis of the South American camelid alpaca (Vicugna pacos).
Liguori G, Assisi L, Squillacioti C, Paino S, Mirabella N, Vittoria A. Gen Comp Endocrinol. 2012;179(1):137-42.

Systemic and nasal delivery of orexin-A (Hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates. J Neurosci.
Deadwyler SA, Porrino L, Siegel JM, Hampson RE. 2007;27(52):14239-47.

Hypocretin/orexin type 1 receptor in brain: role in cardiovascular control and the neuroendocrine response to immobilization stress.
Samson WK, Bagley SL, Ferguson AV, White MM. Am J Physiol Regul Integr Comp Physiol. 2007;292(1):R382-7.

Hypocretin-1 dose-dependently modulates maternal behaviour in mice.
D'anna KL, Gammie SC. J Neuroendocrinol. 2006;18(8):553-66.

PC1/3 and PC2 gene expression and post-translational endoproteolytic pro-opiomelanocortin processing is regulated by photoperiod in the seasonal Siberian hamster (Phodopus sungorus).
Helwig M, Khorooshi RM, Tups A, et al. J Neuroendocrinol. 2006;18(6):413-25.

Food intake in rhesus monkeys following central administration of orexins.
Ramsey JJ, Kemnitz JW, Newton W, Hagopian K, Patterson TA, Swick AG. Regul Pept. 2005;124(1-3):209-14.

Genomic organization of mouse orexin receptors: characterization of two novel tissue-specific splice variants.
Chen J, Randeva HS. Mol Endocrinol. 2004;18(11):2790-804.

Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system.
Karteris E, Chen J, Randeva HS. J Clin Endocrinol Metab. 2004;89(4):1957-62.

Antiallodynic effects of intrathecal orexins in a rat model of postoperative pain.
Cheng JK, Chou RC, Hwang LL, Chiou LC. J Pharmacol Exp Ther. 2003;307(3):1065-71.

Peptides that regulate food intake: regional, metabolic, and circadian specificity of lateral hypothalamic orexin A feeding stimulation.
Thorpe AJ, Mullett MA, Wang C, Kotz CM. Am J Physiol Regul Integr Comp Physiol. 2003;284(6):R1409-17.

Orexin-A depolarizes nucleus tractus solitarius neurons through effects on nonselective cationic and K+ conductances.
Yang B, Ferguson AV. J Neurophysiol. 2003;89(4):2167-75.

Direct and indirect excitation of laterodorsal tegmental neurons by Hypocretin/Orexin peptides: implications for wakefulness and narcolepsy.
Burlet S, Tyler CJ, Leonard CS. J Neurosci. 2002;22(7):2862-72.

Hypocretin/orexin suppresses corticotroph responsiveness in vitro.
Samson WK, Taylor MM. Am J Physiol Regul Integr Comp Physiol. 2001;281(4):R1140-5.

A significant participation of orexin-A, a potent orexigenic peptide, in the preovulatory luteinizing hormone and prolactin surges in the rat.
Kohsaka A, Watanobe H, Kakizaki Y, Suda T, Schiöth HB. Brain Res. 2001;898(1):166-70.

Identification of receptors for neuromedin U and its role in feeding.
Howard AD, Wang R, Pong SS, et al. Nature. 2000;406(6791):70-4.

Agouti-related protein-like immunoreactivity: characterization of release from hypothalamic tissue and presence in serum.
Li JY, Finniss S, Yang YK, et al. Endocrinology. 2000;141(6):1942-50.

Pressor effects of orexins injected intracisternally and to rostral ventrolateral medulla of anesthetized rats.
Chen CT, Hwang LL, Chang JK, Dun NJ. Am J Physiol Regul Integr Comp Physiol. 2000;278(3):R692-7.

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