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Dynorphin A (Human, Rat, Mouse, Porcine)

Quantity:

Catalog #
Size
Price
021-03 500 µg $67

Sequence:  ()
Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln
  • Molecular Weight:
  • 2147.51
  • Purity:
  • ≥ 95%
  • Validation:
  • Exhibits correct molecular weight
  • Solubility:
  • Soluble in water
  • Storage:
  • Up to 6 months in lyophilized form at 0-5°C.
    For best results, rehydrate just before use.
    After rehydration, keep solution at +4°C for up to 5 days or freeze at -20°C for up to 3 months. Aliquot before freezing to avoid repeated freeze-thaw cycles.
  • Appearance:
  • White powder
  • Contents:
  • Each vial contains 500 µg of NET peptide.
  • MSDS:
  • View/Download(PDF)

Dynorphin peptides differentially regulate the human kappa opioid receptor.

Ligands regulate cell surface level of the human kappa opioid receptor by activation-induced down-regulation and pharmacological chaperone-mediated enhancement: differential effects of nonpeptide and peptide agonists.

Differential effects of agonists on adenylyl cyclase superactivation mediated by the kappa opioid receptors: adenylyl cyclase superactivation is independent of agonist-induced phosphorylation, desensitization, internalization, and down-regulation.

Ezrin-radixin-moesin-binding phosphoprotein-50/Na+/H+ exchanger regulatory factor (EBP50/NHERF) blocks U50,488H-induced down-regulation of the human kappa opioid receptor by enhancing its recycling rate.
Li JG, Chen C, Liu-chen LY. J Biol Chem. 2002;277(30):27545-52.

Femtomolar concentrations of dynorphins protect rat mesencephalic dopaminergic neurons against inflammatory damage.
Liu B, Qin L, Yang SN, Wilson BC, Liu Y, Hong JS. J Pharmacol Exp Ther. 2001;298(3):1133-41.

p53 Latency. C-terminal domain prevents binding of p53 core to target but not to nonspecific DNA sequences.

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