Oxytocin (Human, Rat, Mouse, Bovine) – RIA Kit

Catalog #: RK-051-01

Size: 125 tubes

Price: $924

Sensitivity: 6.7 pg/ml
Linear Range: 1.25 – 160 pg/ml
Radioactivity: Each kit contains 1.5 µCi of Iodine 125.
Cross Reactivity:
Peptide %
Oxytocin 100
[Lys8]-Vasopressin 0
[Arg8]-Vasopressin 0
Growth Hormone (Human) 0
α-ANP (1-28) (Human, Canine) 0
Met-Enkephalin 0
GRF (Human) 0
Somatostatin 0
TRH 0
VIP (Human, Porcine, Rat) 0
PACAP 27-NH2 (Human, Ovine, Rat) 0

Standard Curve:

Disclaimer: This package conforms to the 49 CFR173.421 for expected radioactive material limited quantity, N.O.S. UN2910.

A mammalian hormone that acts primarily as a neuromodulator in the brain

Abstract

Biological Functions of Oxytocin and Oxytocin-like Drugs

Neuropeptide oxytocin is of great importance in social and reproductive behavior and emotions. Oxytocin or oxytocin-like drugs have many potential therapeutic applications. This can generate greater interest in testing oxytocin as a treatment for a number of disorders, and in developing central nervous system-penetrating oxytocin agonists suitable for clinical trials. The pharmaceutical industry would be interested in investigating oxytocinergic compounds with regards to the following functions: Addition to stimulating female and male sexual behavior Penile erections Social closeness – including parental and monogamous bonding Diminishes pain, depression, anxiety, aggression and stress hormone release Lowers blood pressure Counteracts addiction and drug withdrawal Modulates appetite and digestive processes Promotes wound healing Few, if any, other neurochemicals have such a broad spectrum of effects.

Moberg, K. The Oxytocin Factor. Perseus, 2003.

Schematics

aa sequence oxytocin

oxytocin schematics
sequence oxytocin
sequence comparison oxytocin

More Information

Oxytocin is a mammalian hormone that acts primarily as a neuromodulator in the brain.

Oxytocin is a mammalian hormone that acts primarily as a neuromodulator in the brain.
Oxytocin is best known for its roles in sexual reproduction, in particular during and after childbirth. It is released in large amounts after distension of the cervix and uterus during labor, facilitating birth, and after stimulation of the nipples, facilitating breastfeeding.
Recent studies have begun to investigate oxytocin’s role in various behaviors, including orgasm, social recognition, pair bonding, anxiety, and maternal behaviors. For this reason, it is sometimes referred to as the “love hormone”. The inability to secrete oxytocin and feel empathy is linked to sociopathy, psychopathy, narcissism and general manipulativeness.
The word oxytocin was derived from the Greek ωκυτοκíνη, okytokíne, meaning “quick birth”, after its uterine-contracting properties were discovered by British pharmacologist Sir Henry Hallett Dale in 1906. The milk ejection property of Oxt was described by Ott and Scott in 1910 and by Schafer and Mackenzie in 1911. The nine amino acid sequence of Oxt was elucidated by Vincent du Vigneaud et al. and by Tuppy in 1953. and synthesized biochemically soon after by du Vigneaud et al. in 1953. Oxytocin was the very first polypeptide hormone to be sequenced and synthesized. 
Biological Functions of Oxytocin and Oxytocin-like Drugsstructure oxytocin
Neuropeptide oxytocin is of great importance in social and reproductive behavior and emotions. Oxytocin or oxytocin-like drugs have many potential therapeutic applications. This can generate greater interest in testing oxytocin as a treatment for a number of disorders, and in developing central nervous system-penetrating oxytocin agonists suitable for clinical trials. The pharmaceutical industry would be interested in investigating oxytocinergic compounds with regards to the following functions:
Addition to stimulating female and male sexual behavior
Penile erections
Social closeness – including parental and monogamous bonding
Diminishes pain, depression, anxiety, aggression and stress hormone release
Lowers blood pressure
Counteracts addiction and drug withdrawal
Modulates appetite and digestive processes
Promotes wound healing
Few, if any, other neurochemicals have such a broad spectrum of effects.
Moberg, K. The Oxytocin Factor. Perseus, 2003.

Effects of selective serotonin reuptake inhibitor treatment on plasma oxytocin and cortisol in major depressive disorder.
Keating C, Dawood T, Barton DA, Lambert GW, Tilbrook AJ. BMC Psychiatry. 2013;13:124.

Evaluation of enzyme immunoassay and radioimmunoassay methods for the measurement of plasma oxytocin.
Szeto A, Mccabe PM, Nation DA, et al. Psychosom Med. 2011;73(5):393-400.

A relationship between oxytocin and anxiety of romantic attachment.
Marazziti D, Dell’osso B, Baroni S, et al. Clin Pract Epidemiol Ment Health. 2006;2:28.

Social experience influences hypothalamic oxytocin in the WHHL rabbit.
Paredes J, Szeto A, Levine JE, et al. Psychoneuroendocrinology. 2006;31(9):1062-75.

Prolactin secretory rhythm of mated rats induced by a single injection of oxytocin.
Egli M, Bertram R, Toporikova N, Sellix MT, Blanco W, Freeman ME. Am J Physiol Endocrinol Metab. 2006;290(3):E566-72.

Short-term effects of alcohol consumption on the hormonal milieu and mood states in nulliparous women.
Mennella JA, Pepino MY. Alcohol. 2006;38(1):29-36.

Acute alcohol consumption disrupts the hormonal milieu of lactating women.
Mennella JA, Pepino MY, Teff KL. J Clin Endocrinol Metab. 2005;90(4):1979-85.

Rhythmic secretion of prolactin in rats: action of oxytocin coordinated by vasoactive intestinal polypeptide of suprachiasmatic nucleus origin.
Egli M, Bertram R, Sellix MT, Freeman ME. Endocrinology. 2004;145(7):3386-94.

Plasma oxytocin during intense exercise in professional cyclists.
Chicharro JL, Hoyos J, Bandrés F, Gómez gallego F, Pérez M, Lucía A. Horm Res. 2001;55(3):155-9.

The role of oxytocin in relation to female sexual arousal.
Blaicher W, Gruber D, Bieglmayer C, Blaicher AM, Knogler W, Huber JC. Gynecol Obstet Invest. 1999;47(2):125-6.

Related Products

Catalog
Product
Size
Price
Buy Now
RK-APRO
Aprotinin, 30 Trypsin Inhibitory Units (TIU)
Catalog: RK-APRO
5 ml
Size:5 ml
$116
Price: $116
VT-6450
Lavender Vacutainer Tubes
Catalog: VT-6450
100 tubes
Size:100 tubes
$261
Price: $261