Somatostatin (Human, Rat, Mouse, Porcine) – EIA Kit

Catalog #: EK-060-03

Size: 96 wells

Price: $599

Intra-assay variation: <10%
Inter-assay variation: <15%

Linear Range: 0.13 – 1.16 ng/ml
Sensitivity: 0.13 ng/ml
Sample Extraction: Recommended
Cross Reactivity:
Peptide %
Somatostatin 100
Somatostatin-28 100
Somatostatin-25 100
[Des-Ala1]-Somatostatin 100
Somatostatin (1-32) 0
Pro-Somatostatin-32 0
Somatostatin Analog, RC-160 0
Somatostatin Analog (CTOP) 0
Octreotide 0
Insulin (Human) 0
Glucagon (Human) 0
Amylin (Human) 0
Substance P 0
VIP (Human, Porcine, Rat) 0
NPY (Porcine) 0

Standard Curve:

Somatostatin is a diverse peptide hormone that shows various physiological effects between species

Abstract

Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads

Abstract: Somatostatin (SS) is a peptide hormone with diverse physiological roles. By investigating a deep-water clade of fish-hunting cone snails, we show that predator-prey evolution has generated a diverse set of SS analogs, each optimized to elicit specific systemic physiological effects in prey. The increased metabolic stability, distinct SS receptor activation profiles, and chemical diversity of the venom analogs make them suitable leads for therapeutic application, including pain, cancer, and endocrine disorders. Our findings not only establish the existence of SS-like peptides in animal venoms but also serve as a model for the synergy gained from combining molecular phylogenetics and behavioral observations to optimize the discovery of natural products with biomedical potential.

 

Ramiro IBL, Bjørn-Yoshimoto WE, Imperial JS, et al. Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads. Sci Adv. 2022;8(12):eabk1410.

Schematics

Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice.
Uchida K, Dezaki K, Damdindorj B, et al. Diabetes. 2011;60(1):119-26.

Somatostatin preserved blood brain barrier against cytokine induced alterations: possible role in multiple sclerosis.
Basivireddy J, Somvanshi RK, Romero IA, et al. Biochem Pharmacol. 2013;86(4):497-507.

Somatostatin receptor 5 and cannabinoid receptor 1 activation inhibit secretion of glucose-dependent insulinotropic polypeptide from intestinal K cells in rodents.
Moss CE, Marsh WJ, Parker HE, et al. Diabetologia. 2012;55(11):3094-103.

Dual regulatory role for phosphatase and tensin homolog in specification of intestinal endocrine cell subtypes.
Roy SA, Langlois MJ, Carrier JC, Boudreau F, Rivard N, Perreault N. World J Gastroenterol. 2012;18(14):1579-89.

Cell-to-cell communication and cellular environment alter the somatostatin status of delta cells.
Kelly C, Flatt PR, Mcclenaghan NH. Biochem Biophys Res Commun. 2010;399(2):162-6.

The role of glucagon- and somatostatin-secreting cells in the regulation of insulin release and beta-cell function in heterotypic pseudoislets.
Kelly C, Parke HG, Mccluskey JT, Flatt PR, Mcclenaghan NH. Diabetes Metab Res Rev. 2010;26(7):525-33.

Relation between stressful life events, neuropeptides and cytokines: results from the LISA birth cohort study.
Herberth G, Weber A, Röder S, et al. Pediatr Allergy Immunol. 2008;19(8):722-9.

Bravo capsule system optimizes intragastric pH monitoring over prolonged time: effects of ghrelin on gastric acid and hormone secretion in the rat.
Rudholm T, Hellstrom PM, Theodorsson E, Campbell CA, Mclean PG, Naslund E. World J Gastroenterol. 2008;14(40):6180-7.

SA13353 (1-[2-(1-Adamantyl)ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea) inhibits TNF-alpha production through the activation of capsaicin-sensitive afferent neurons mediated via transient receptor potential vanilloid 1 in vivo.
Murai M, Tsuji F, Nose M, et al. Eur J Pharmacol. 2008;588(2-3):309-15.

Decreased bile acid synthesis with total parenteral nutrition.
Dawes LG, Laut HC, Woodruff M. Am J Surg. 2007;194(5):623-7.

Attenuation of insulin secretion by insulin-like growth factor binding protein-1 in pancreatic beta-cells.
Zhang F, Sjöholm Å, Zhang Q. Biochem Biophys Res Commun. 2007;362(1):152-7.

Association of neuropeptides with Th1/Th2 balance and allergic sensitization in children.
Herberth G, Daegelmann C, Weber A, et al. Clin Exp Allergy. 2006;36(11):1408-16.

Characterization of the bystander effect of somatostatin receptor sst2 after in vivo gene transfer into human pancreatic cancer cells.
Carrere N, Vernejoul F, Souque A, et al. Hum Gene Ther. 2005;16(10):1175-93.

Partial sleep deprivation compromises gastric mucosal integrity in rats.
Guo JS, Chau JF, Cho CH, Koo MW. Life Sci. 2005;77(2):220-9.

Leptin stimulates growth hormone secretion via a direct pituitary effect combined with a decreased somatostatin tone in a median eminence-pituitary perifusion study.
Saleri R, Giustina A, Tamanini C, et al. Neuroendocrinology. 2004;79(4):221-8.

A novel variant of ionotropic glutamate receptor regulates somatostatin secretion from delta-cells of islets of Langerhans.
Muroyama A, Uehara S, Yatsushiro S, et al. Diabetes. 2004;53(7):1743-53.

Delayed liquid gastric emptying in patients with hepatocellular carcinoma.
Chen CY, Lu CL, Chang FY, et al. Am J Gastroenterol. 2000;95(11):3230-7.

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