Irisin, recombinant (Human, Rat, Mouse, Canine)


Catalog #
067-29A 100 µg $892

Sequence:  ()
GS at N-terminus from thrombin cleavage site.
  • CAS Number:
  • 9037-90-5
  • Validation:
  • Exhibits correct molecular weight
  • Solubility:
  • Soluble in water (0.1-1.0 mg/ml). Then dilute with water or any desired aqueous buffer.
  • Storage:
  • Store in dried form at -80°C for up to 3 months.
    For best results, rehydrate just before use.
    After rehydration, keep at +4°C for 1 week or at -80°C for longer-term storage. Aliquot before freezing to avoid repeated freeze-thaw cycles.
  • Appearance:
  • White powder
  • Contents:
  • Each vial contains 100 µg of protein.

Irisin is induced in renal ischemia-reperfusion to protect against tubular cell injury via suppressing p53.
Liu Y, Fu Y, Liu Z, et al. Biochim Biophys Acta Mol Basis Dis. 2020;1866(7):165792.

Recombinant Irisin Prevents the Reduction of Osteoblast Differentiation Induced by Stimulated Microgravity through Increasing β-Catenin Expression.
Chen Z, Zhang Y, Zhao F, et al. Int J Mol Sci. 2020;21(4)

Irisin reverses intestinal epithelial barrier dysfunction during intestinal injury via binding to the integrin αVβ5 receptor.
Bi J, Zhang J, Ren Y, et al.  J Cell Mol Med. 2020;24(1):996-1009.

Irisin promotes proliferation but inhibits differentiation in osteoclast precursor cells.
Ma Y, Qiao X, Zeng R, et al.  FASEB J. 2018;:fj201700983RR.

Effects and underlying mechanisms of irisin on the proliferation and apoptosis of pancreatic β cells. 
Liu S, Du F, Li X, et al. PLoS ONE. 2017;12(4):e0175498.

Exercise-indusced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism.
Zhang J, Valverde P, Zhu X, et al. Bone Research. 2017;5:16056.

Irisin Lowers Blood Pressure by Improvement of Endothelial Dysfunction via AMPK-Akt-eNOS-NO Pathway in the Spontaneously Hypertensive Rat.
Fu J, Han Y, Wang J, et al. J Am Heart Assoc. 2016;5(11)

FNDC5 expression and circulating irisin levels are modified by diet and hormonal conditions in hypothalamus, adipose tissue and muscle.
Varela-rodríguez BM, Pena-bello L, Juiz-valiña P, Vidal-bretal B, Cordido F, Sangiao-alvarellos S. Sci Rep. 2016;6:29898.

Irisin evokes bradycardia by activating cardiac-projecting neurons of nucleus ambiguus.
Brailoiu E, Deliu E, Sporici RA, Brailoiu GC. Physiol Rep. 2015;3(6)

Central and peripheral irisin differentially regulate blood pressure.
Zhang W, Chang L, Zhang C, et al. Cardiovasc Drugs Ther. 2015;29(2):121-7.

Irisin, a Novel Myokine, Regulates Glucose Uptake in Skeletal Muscle Cells via AMPK.
Lee HJ, Lee JO, Kim N, et al. Mol Endocrinol. 2015;29(6):873-81.

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