Catalog # |
Size |
Price |
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|---|---|---|---|
| RK-060-03 | 125 tubes | $880 |
| View/Download (PDF) - for reference only | |||||||||||||||||||||||
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| Suggested Procedure | ||||||||||||||||||||||
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| Recommended | ||||||||||||||||||||||
 Data may differ slightly based on lot. | 37.7 pg/ml | ||||||||||||||||||||||
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| 10 - 1280 pg/ml | ||||||||||||||||||||||
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| Each kit contains 1.5 µCi of Iodine 125. | ||||||||||||||||||||||
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| This package conforms to the 49 CFR173.421 for expected radioactive material limited quantity, N.O.S. UN2910. | ||||||||||||||||||||||
Abstract: Somatostatin (SS) is a peptide hormone with diverse physiological roles. By investigating a deep-water clade of fish-hunting cone snails, we show that predator-prey evolution has generated a diverse set of SS analogs, each optimized to elicit specific systemic physiological effects in prey. The increased metabolic stability, distinct SS receptor activation profiles, and chemical diversity of the venom analogs make them suitable leads for therapeutic application, including pain, cancer, and endocrine disorders. Our findings not only establish the existence of SS-like peptides in animal venoms but also serve as a model for the synergy gained from combining molecular phylogenetics and behavioral observations to optimize the discovery of natural products with biomedical potential.
Ramiro IBL, Bjørn-Yoshimoto WE, Imperial JS, et al. Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads. Sci Adv. 2022;8(12):eabk1410.
Links to publications that use this kit:
Samson et al. Neuronostatin encoded by the somatostatin gene regulates neuronal, cardiovascular, and metabolic functions.Reddy et al. Pioglitazone reverses insulin resistance and impaired CCK-stimulated pancreatic secretion in eNOS(-/-) mice: therapy for exocrine pancreatic disorders?
Am J Physiol Gastrointest Liver Physiol. 2007 Jul;293(1):G112-20.
Ait-Lounis et al. Novel Function of the Ciliogenic Transcription Factor RFX3 in Development of the Endocrine Pancreas
Diabetes. 2007 Apr;56(4):950-9.
Givalois et al. Involvement of brain-derived neurotrophic factor in the regulation of hypothalamic somatostatin in vivo
J Endocrinol. 2006 Mar;188(3):425-33.
Timper et al. Human adipose tissue-derived mesenchymal stem cells differentiate into insulin, somatostatin, and glucagon expressing cells.
Biochem Biophys Res Commun. 2006 Mar 24;341(4):1135-40.
Francis et al. cAMP stimulates the secretory and proliferative capacity of the rat intrahepatic biliary epithelium through changes in the PKA/Src/MEK/ERK1/2 pathway.
J Hepatol. 2004 Oct;41(4):528-37.
Seboek et al. Somatostatin is expressed and secreted by human adipose tissue upon infection and inflammation.
J Clin Endocrinol Metab. 2004 Oct;89(10):4833-9.
Araujo et al. Restoration of insulin secretion in pancreatic islets of protein-deficient rats by reduced expression of insulin receptor substrate (IRS)-1 and IRS-2.
J Endocrinol. 2004 Apr;181(1):25-38.
Araujo et al. Blockade of IRS1 in isolated rat pancreatic islets improves glucose-induced insulin secretion.
FEBS Lett. 2002 Nov 20;531(3):437-42.
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